The 2010 NHL Draft was defined by the "Taylor vs. Tyler" (Hall and Seguin) debate at #1 and #2. The round was deep with talent like Ryan Johansen (#4), Jeff Skinner (#7), and Cam Fowler (#12). Vladimir Tarasenko (#16) and Evgeny Kuznetsov (#26) brought elite scoring touch, while Mark Stone was the ultimate win at 178th overall. Overall, 2010 was an offensive-minded draft that produced several elite goal scorers. While the top two picks eventually moved on from their original teams, both became stars who justified their massive pre-draft hype.
Career earnings of players picked in the first round of the 2010 NHL entry draft.
| Taylor Hall | LW | 1 | Edmonton Oilers | $79,826,829 | 87 | $98,784,260 | 123 |
| Tyler Seguin | C | 2 | Boston Bruins | $108,876,829 | 22 | $131,780,870 | 49 |
| Erik Gudbranson | D | 3 | Florida Panthers | $44,276,829 | 359 | $53,715,505 | 424 |
| Ryan Johansen | C | 4 | Columbus Blue Jackets | $74,710,000 | 106 | $90,386,682 | 155 |
| Nino Niederreiter | RW | 5 | New York Islanders | $52,460,000 | 262 | $63,515,986 | 323 |
| Brett Connolly | RW | 6 | Tampa Bay Lightning | $18,792,166 | 901 | $23,612,897 | 1011 |
| Jeff Skinner | C | 7 | Carolina Hurricanes | $97,565,717 | 38 | $118,932,437 | 69 |
| Alexander Burmistrov | C | 8 | Atlanta Thrashers | $11,154,102 | 1273 | $15,210,710 | 1350 |
| Mikael Granlund | F | 9 | Minnesota Wild | $56,326,829 | 221 | $66,887,755 | 298 |
| Dylan McIlrath | D | 10 | New York Rangers | $5,392,783 | 1897 | $6,306,697 | 2190 |
| Jack Campbell | G | 11 | Dallas Stars | $21,200,000 | 829 | $23,678,508 | 1007 |
| Cam Fowler | D | 12 | Anaheim Ducks | $74,326,829 | 107 | $89,958,057 | 156 |
| Brandon Gormley | D | 13 | Phoenix Coyotes | $2,560,500 | 2681 | $3,589,482 | 2850 |
| Jaden Schwartz | C | 14 | St. Louis Blues | $61,066,829 | 184 | $73,334,333 | 247 |
| Derek Forbort | D | 15 | Los Angeles Kings | $20,750,000 | 841 | $24,090,261 | 995 |
| Vladimir Tarasenko | RW | 16 | St. Louis Blues | $76,826,829 | 100 | $94,119,173 | 136 |
| Joey Hishon | C | 17 | Colorado Avalanche | $900,000 | 3936 | $1,289,544 | 4146 |
| Austin Watson | LW | 18 | Nashville Predators | $9,946,870 | 1372 | $12,144,991 | 1530 |
| Nick Bjugstad | C | 19 | Florida Panthers | $34,676,829 | 522 | $43,196,995 | 586 |
| Beau Bennett | RW | 20 | Pittsburgh Penguins | $3,151,829 | 2433 | $4,298,262 | 2628 |
| Riley Sheahan | C | 21 | Detroit Red Wings | $12,425,500 | 1194 | $16,329,968 | 1290 |
| Jarred Tinordi | D | 22 | Montreal Canadiens | $7,287,329 | 1627 | $8,966,487 | 1832 |
| Mark Pysyk | D | 23 | Buffalo Sabres | $13,850,000 | 1115 | $17,729,799 | 1224 |
| Kevin Hayes | RW | 24 | Chicago Blackhawks | $62,175,000 | 174 | $73,168,975 | 251 |
| Quinton Howden | C | 25 | Florida Panthers | $1,377,329 | 3464 | $1,896,077 | 3690 |
| Evgeny Kuznetsov | C | 26 | Washington Capitals | $67,285,000 | 143 | $83,176,697 | 189 |
| Charlie Coyle | C/RW | 28 | San Jose Sharks | $49,826,829 | 291 | $59,444,507 | 353 |
| Emerson Etem | RW | 29 | Anaheim Ducks | $2,186,829 | 2893 | $2,998,139 | 3104 |
| Brock Nelson | C | 30 | New York Islanders | $59,576,829 | 202 | $69,998,286 | 273 |